CDC123 多克隆抗体

Western Blot（WB）已验证样本:293T,Hela

WB 1:500-1:2000, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human CDC123

CDC123

C10orf7;CD123;CDC123;Cell division cycle 123;Cell division cycle 123 homolog;Cell division cycle protein 123 homolog;D123;HT 1080;HT-1080;Protein D123;PZ32抗体

O75794

39 kDa

Refer to figures

Cytoplasm.

0.9 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Cell Biology

Unconjugated

The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.