RBFOX3 多克隆抗体

Western Blot（WB）已验证样本:Jurkat
免疫组织化学（IHC）已验证样本:Human brain

WB 1:200-1:1000 , IHC 1:50-200

Polyclonal

IgG

Synthetic peptide of human RBFOX3

RBFOX3

FLJ56884;FLJ58356;Fox-1 homolog C;fox1 homolog C;Fox3;FOX3NeuN;hexaribonucleotide binding protein 3;HRNBP3;NEUN;neuronal nuclei;Rbfox3;RFOX3;RNA binding protein fox-1 homolog 3;RNA binding protein;fox 1 homolog (C. elegans) 3抗体

A6NFN3

34kDa

Refer to figures

Nucleus. Cytoplasm.

0.1 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Epigenetics and Nuclear Signaling; Neuroscience; Tags and Cell Markers

Unconjugated

Immunoprecipitation and mass spectrometry of the two major NeuN species at 45–50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.