LRP6 Polyclonal Antibody 货号：E-

Verified Samples in IHC: Human liver cancer

IHC 1:40-200

Polyclonal

IgG

Synthetic peptide of human LRP6

LRP6

ADCAD2, C030016K15Rik, Cd, FLJ90062, FLJ90421, LDL receptor related protein 6, LRP-6, LRP6, Low density lipoprotein receptor related protein 6, Low-density lipoprotein receptor-related protein 6, OTTHUMP00000238979, OTTHUMP00000238980, OTTHUMP00000238982, STHAG7

O75581

Membrane. Endoplasmic reticulum. On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD.

1.4 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, pH 7.4.

Affinity purification

Cancer, Signal transduction, Stem cells

Unconjugated

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.