NPRL2 多克隆抗体

免疫组织化学（IHC）已验证样本:Human liver cancer,Human thyroid cancer

IHC 1:50-1:200

Polyclonal

IgG

Synthetic peptide of human NPRL2

NPRL2

2810446G01Rik;G21 protein;Gene 21 protein;Homologous to yeast nitrogen permease (candidate tumor suppressor);Homologous to yeast nitrogen permease;Nitrogen permease regulator 2-like protein;Nitrogen permease regulator-like 2 (S. cerevisiae);NPR 2L;NPR L2;NPR like 2;NPR2;NPR2 like;NPR2-like protein;NPR2L;NPRL 2;NPRL2;NPRL2;Tumor suppressor candidate 4;TUSC 4;TUSC 4 protein;TUSC4;TUSC4 protein抗体

Q8WTW4

Lysosome,lysosomal membrane,Other locations:GATOR1 complex

0.9 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Epigenetics and Nuclear Signaling

Unconjugated

NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.