SCN1A 多克隆抗体

免疫组织化学（IHC）已验证样本:Human cervical cancer,Human esophagus cancer

IHC 1:50-1:200

Polyclonal

IgG

Synthetic peptide of human SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/13A

SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/13A

brain sodium channel type I;EIEE6;FEB3;FEB3A;FHM3;GEFS+2;GEFSP2;HBSC I;HBSCI;NAC1;Nav 1.1;RBI;SCN1;Scn1a;SCN1A;SMEI;Sodium channel protein brain I alpha subunit;Sodium channel protein brain I subunit alpha;Sodium channel protein type 1 subunit alpha;Sodium channel protein type I subunit alpha;Sodium channel voltage gated type 1 alpha subunit;Sodium channel voltage gated type I alpha polypeptide;Voltage-gated sodium channel subunit alpha Nav1.1抗体

P35498

Membrane.

0.5 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Neuroscience

Unconjugated

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.