KCNQ1 多克隆抗体

Western Blot（WB）已验证样本:Mouse heart
免疫组织化学（IHC）已验证样本:Human breast cancer

WB 1:200-1:1000, IHC 1:50-1:200

Polyclonal

IgG

Recombinant protein of human KCNQ1

KCNQ1

ATFB1;ATFB3;FLJ26167;IKs producing slow voltage-gated potassium channel subunit alpha;IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1;Jervell and Lange-Nielsen syndrome 1;JLNS1;KCNA8;KCNA9;KCNQ1;KCNQ1;kidney and cardiac voltage dependend K+ channel;KQT-like 1;Kv1.9;Kv7.1;KVLQT1;long (electrocardiographic) QT syndrome;Ward-Romano syndrome 1;LQT;LQT1;Potassium channel;voltage-gated;shaker-relatd subfamily;member 9;Potassium voltage-gated channel subfamily KQT member 1;potassium voltage-gated channel;KQT-like subfamily;member 1;RWS;slow delayed rectifier channel subunit;SQT2;Voltage-gated potassium channel subunit Kv7.1;WRS抗体

P51787

75kDa

Cell membrane. Cytoplasmic vesicle membrane. Early endosome. Membrane raft. Endoplasmic reticulum. Basolateral cell membrane. Colocalized with KCNE3 at the plasma membrane (PubMed:10646604). Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome (PubMed:23529131). Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains (PubMed:24855057). During the early stages of epithelial cell polarization induced by the calcium switch it removed from plasma membrane to the endoplasmic reticulum where it retained and it is redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage (PubMed:21228319).

0.2 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction

Unconjugated

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.