COPB1 多克隆抗体

Western Blot（WB）已验证样本:Raji
免疫组织化学（IHC）已验证样本:Human thyroid cancer,Human gastric cancer

WB 1:200-1:1000, IHC 1:50-1:200

Polyclonal

IgG

Recombinant protein of human COPB1

COPB1

Beta-coat protein;Beta-COP;betacop;Coatomer beta subunit;Coatomer protein complex subunit beta 1;Coatomer protein complex subunit beta;Coatomer subunit beta;COPB;COPB;Copb1;DKFZp761K102;FLJ10341抗体

P53618

107kDa

Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle>COPI-coated vesicle membrane. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (By similarity). Found in perinuclear vesicular-tubular clusters (VTCs) and in the Golgi region where associated with vesicles, buds and rims of the Golgi stack (By similarity). Occasionally present at the trans-side of Golgi, but mainly present at the cis-Golgi side in transitional areas (TA), on so-called peripheral elements (PE) consisting of tubules and vesicles located between the cup-shaped transitional elements (TE) of the rough endoplasmic reticulum (RER) and the cis-most Golgi cisternae (By similarity). Present in cytoplasm, not associated with visible coats or membranes, with a minor fraction present on small clusters of tubules and vesicles (By similarity). Some association with high-density and low-density microsomes and mitochondria/nuclei fraction (By similarity). Very little found in plasma membrane fraction.

0.5 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Signal Transduction

Unconjugated

This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described.