CCDC88A 多克隆抗体

免疫组织化学（IHC）已验证样本:Human cervical cancer,Human colon cancer

IHC 1:50-1:200

Polyclonal

IgG

Synthetic peptide of human CCDC88A

CCDC88A

AKT iphosphorylation enhancer;Akt phosphorylation enhancer;APE;Ccdc88a;Coiled coil domain containing 88A;Coiled coil domain containing protein 88A;Coiled-coil domain-containing protein 88A;FLJ10392;G alpha interacting vesicle associated protein;G alpha-interacting vesicle-associated protein;Galpha interacting vesicle associated protein;Girders of actin filament;Girdin;GIV;GRDN;GRDN;HkRP1;Hook related protein 1;Hook-related protein 1;KIAA1212抗体

Q3V6T2

Membrane. Cell membrane. Cytoplasm>cytosol. Cytoplasmic vesicle. Cell projection>lamellipodium. Localizes to the cell membrane through interaction with phosphoinositides.

1 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Neuroscience; Signal Transduction

Unconjugated

This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.