KDM4D 多克隆抗体

免疫组织化学（IHC）已验证样本:Human prostate cancer

IHC 1:25-1:100

Polyclonal

IgG

Recombinant protein of human KDM4D

KDM4D

JHD3D;JHDM3D;JmjC domain-containing histone demethylation protein 3D;Jumonji domain-containing protein 2D;Kdm4d;KDM4D;Lysine-specific demethylase 4D抗体

Q6B0I6

Nucleus.

0.3 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Epigenetics and Nuclear Signaling

Unconjugated

JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.