- 询价
- Cell Signaling Technology
- 2431
- USA
- 2025年11月26日
- W
- Rabbit
- H,M
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- 详细信息
- 技术资料
- 抗体英文名：
Phospho-Shc (Tyr317) Antibody
- 抗原：
synthetic phosphopeptide corresponding to residues surrounding Tyr317 of human Shc
- 应用范围：
W
- 宿主：
Rabbit
- 适应物种：
H,M
- 库存：
大量
- 供应商：
CST
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M | Endogenous | 50, 55, 70 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Phospho-Shc (Tyr317) Antibody detects Shc only when phosphorylated at Tyr317. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr317 of human Shc. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from A431 and HepG2 cells, untreated or EGF-treated (100 ng/ml) after 24 hours of serum-starvation, using Phospho-Shc (Tyr317) Antibody (upper) or Shc antibody (lower). |
| Background | Shc possesses SH2 and PTB domains and serves as a scaffold protein in signaling for a variety of receptor tyrosine kinases. Shc exists in p46, p52 and p66 isoforms, which are produced by using alternative translation initiation sites or a differentially spliced message (1-3). In response to extracellular signals, the SH2 and PTB domains of Shc interact with the activated receptors, leading to phosphorylation of Shc on three different tyrosine residues: Tyr239, Tyr240 and Tyr317 (4-6). GRB2/Sos binds to Shc phosphorylated at these sites, activating the Ras/Raf/MAPK pathway (4). Both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development (7).
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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