- 询价
- Cell Signaling Technology
- 4235
- USA
- 2025年12月10日
- W
- Rabbit
- H,R,M
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- 详细信息
- 询价记录
- 技术资料
- 抗体英文名：
NG2 Antibody
- 抗原：
synthetic peptide surrounding His2260 of human NG2
- 应用范围：
W
- 宿主：
Rabbit
- 适应物种：
H,R,M
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 库存：
大量
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H R (M) | Endogenous | 250 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | NG2 Antibody detects endogenous levels of total NG2 protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding His2260 of human NG2. Antibodies are purified by peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from MDA-MB-468 and RN33B cells using NG2 Antibody. |
| Background | The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells. Normal precursor cells and malignant tumor cells migrate and proliferate, but there is evidence that cells may not be able to engage in both activities at the same time. However, NG2 is involved in promoting both proliferation and motility (1). The extracellular domain of NG2 sequesters growth factors and binds to both growth factor receptors and extracellular matrix ligands such as fibronectin, collagens and laminin. The cytoplasmic domain is involved in activating Rac, Cdc42 and p130 Cas (2). PKCα phosphorylates NG2 at Thr2256, triggering the redistribution of NG2 from apical microprocesses to lamellipodia accompanied by enhanced cell motility (3). ERK phosphorylates NG2 at Thr2314, stimulating cell proliferation (4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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