- 询价
- Cell Signaling Technology
- 4608
- USA
- 2025年08月29日
- W, IP, IF-IC
- Rabbit
- H
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- 详细信息
- 技术资料
- 抗体英文名：
MAML1 Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding His811 of human MAML1
- 应用范围：
W, IP, IF-IC
- 宿主：
Rabbit
- 供应商：
CST
- 适应物种：
H
- 保质期：
详见说明书
- 库存：
大量
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IF-IC | H | Endogenous | 130 | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | MAML1 Antibody detects endogenous levels of total MAML1 protein. It does not cross-react with MAML2 and MAML3. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His811 of human MAML1. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of total cell lysates from HeLa and 293 cells, using MAML1 antibody. IF-IC
Confocal immunofluorescent analysis of MCF-7 cells labeled with MAML1 Antibody (green). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). |
| Background | Mastermind-like (MAML) family of proteins are homologs of Drosophila Mastermind. The family is composed of three members in mammals: MAML1, MAML2, and MAML3 (1,2). MAML complexes with the intracellular domain of Notch (ICN) and the transcription factor CSL (RBP-Jκ) to regulate Notch target gene expression (3-5). MAML1 also interacts with MEF2C (myocyte enhancer factor 2C) to regulate myogenesis (6). MAML2 is frequently found to be fused with Mucoepidermoid carcinoma translocated gene 1 (MECT1, also know as WAMTP1 or TORC1) in patients with mucoepidermoid carcinomas and Warthin's tumors (7).
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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