- ￥1727 - 6000
- MedChemExpress(MCE)
- 美国
- HY-120448A
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2989537-78-0
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥1727.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥3800.0 |
| 规格： | 10 mg | 产品价格： | ￥6000.0 |
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QTX125 TFA
MCE 国际站：QTX125 TFA
产品活性：QTX125 TFA 是一种有效且高度选择性的 HDAC6 抑制剂。与其他 HDAC 相比，QTX125 对 HDAC6 具有出色的选择性。QTX125 TFA 具有抗肿瘤作用。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Apoptosis
In Vitro: QTX125 (25-500 nM; 24-48 hours) TFA treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
?In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 TFA (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin.
?QTX125 TFA has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL).
In Vivo: QTX125 TFA (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice.
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