Cyclizine,5897-19-8

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Cyclizine lactate

CAS No. : 5897-19-8

MCE 国际站：Cyclizine lactate

产品活性：Cyclizine lactate，一种哌嗪衍生物，是一种有效的选择性组胺 H1 受体拮抗剂。Cyclizine lactate 可用于恶心、呕吐和头晕的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Cyclizine (100 μM) lactate significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.
Cyclizine lactate inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC₅₀ of 5.42 µM.

In Vivo: Cyclizine (1-10 mg/kg) lactate enhances locomotor activity of mice in a dose-dependent manner.

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