- 询价
- Cell Signaling Technology
- 3362
- USA
- 2025年08月24日
- W
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
CaMKII (pan) Antibody
- 抗原：
synthetic peptide corresponding to the amino-terminal region of human CaMKII
- 应用范围：
W
- 宿主：
Rabbit
- 保质期：
详见说明书
- 适应物种：
H,M,R,Mk
- 供应商：
CST
- 级别：
详见MSDS文件
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R Mk | Endogenous | 60, 50 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | CaMKII (pan) Antibody detects endogenous levels of total CaMKII. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal region of human CaMKII. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from rat and mouse brain using CaMKII (pan) Antibody. |
| Background | CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling (1,2). CaMKII has catalytic and regulatory domains. The binding of Ca2+ /calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase (3). The activated CaMKII further autophosphorylates at Thr286 to render the kinase constitutively active (3). The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286. PKA (protein kinase A) prevents this dephosphorylation through its inhibitory effect on PP1 (4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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Design of a Human Synthetic Combinatorial Library of Single-Chain Antibodies
) and additional display and screening technologies were applied to pan out desired binding specificities from antibody libraries. “Synthetic” or “semi-synthetic” libraries are from na�ve, non-immunized source and considered to be a source for many different
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