- 询价
- Cell Signaling Technology
- 9581
- USA
- 2025年08月27日
- W, IP, IF-F
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
β-Catenin Antibody (Amino-terminal Antigen)
- 抗原：
synthetic peptide corresponding to residues surrounding Asp56 of human β-catenin
- 应用范围：
W, IP, IF-F
- 宿主：
Rabbit
- 库存：
大量
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk
- 供应商：
CST
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-F=Immunofluorescence (Frozen) ChIP=Chromatin IP
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IF-F | H M R Mk | Endogenous | 92 kDa | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | Beta-Catenin Antibody detects endogenous levels of total β-catenin protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp56 of human β-catenin. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of total cell extracts from 293 and NIH/3T3 cells, using β-Catenin Antibody (Amino-terminal Antigen). IF-F
Confocal immunofluorescence image of mouse colon labeled with β-Catenin Antibody (Amino-terminal Antigen) (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
| Background | β-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Crystallographic Studies of Antigen-Antibody Interactions
and the nature of interactions between amino acid residues. In cases where structures of both liganded and unliganded forms of an antigen or antibody fragment are known, crystallographic studies have led to a more dynamic view of binding, often showing
The Use of Antigen Microarrays in Antibody Profiling
Technological advances in the field of microarray production and analysis lead to the development of protein microarrays. Of these, antigen microarrays are one particular format that allows the study of antigen–antibody interactions
Mapping Antibody:Antigen Interactions by Mass Spectrometry and Bioinformatics
Characterization of the antigen/antibody complex is an important tool in the rational design of antibody-based therapeutics. This can be achieved using several methods. Conventional methods for mapping an antibody-binding region on an antigen
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