Pinocembrin

一种具有多种生物活性的类黄酮；200µM浓度下诱导SKOV3卵巢癌细胞凋亡并抑制其迁移；5mg/kg浓度下减少胶原酶诱发的ICH小鼠模型中的病变体积以及脑小胶质细胞活化和IL-1β、IL-6和TNF-α的产生；防止糖尿病肾病大鼠模型中血浆和肾脏MDA水平升高、肾小球分叶、系膜细胞扩张和小管空泡化和阻塞，并降低肝脏胆固醇、甘油三酯和LDL水平；20和50mg/kg浓度下减少LPS诱发的肺损伤小鼠模型中的肺水肿以及中性粒细胞、淋巴细胞和巨噬细胞浸润。A flavonoid with diverse biological activities; induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells at 200 µM; reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced ICH at 5 mg/kg; prevents increases in plasma and kidney MDA levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy; reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury at 20 and 50 mg/kg.