SC144 (hydrochloride)

gp130抑制剂；20µM浓度下可抑制OVCAR-8卵巢癌细胞中LIF和IL-6而非IFN-γ诱导的STAT1、STAT3和Akt磷酸化；诱导MDA-MB-435乳腺癌和HT-29结直肠癌细胞在G0/G1期周期停滞，并抑制14种癌细胞系增殖(IC50s=0.4-4µM)；降低OVCAR-8和MDA-MB-435小鼠异种移植模型中的肿瘤生长。A gp130 inhibitor; inhibits phosphorylation of STAT1, STAT3, and Akt induced by LIF and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells at 20 µM; induces cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines (IC50s = 0.4-4 µM); reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.