Talniflumate

尼氟酸的前体药物形式；浓度为100µM时，可降低小鼠分离肠绒毛上皮细胞中氯化物/碳酸氢盐交换的速率；饮食给药可增加存活率，但对远端肠梗阻综合征囊性纤维化小鼠模型中空肠或盲肠中的隐窝杯状细胞数量没有影响（88mg/kg）。A prodrug form of niflumic acid; decreases the rate of chloride/bicarbonate exchange in isolated mouse intestinal villous epithelial cells at 100 µM; dietary administration increases survival but has no effect on the number of crypt goblet cells in the jejunum or cecum in a cystic fibrosis mouse model of distal intestinal obstructive syndrome at 88 mg/kg.