Tanshinone IIA sulfonate (sodi

具有免疫调节活性的丹参酮IIA衍生物；减少CSE诱导的IL-6和IL-8分泌并防止CSE诱导的16HBE细胞中CFTR水平下降；在5mg/kg时减少CS诱导的COPD小鼠模型中的肺功能下降、粘液产生、支气管胶原沉积和气腔扩大；在15mg/kg时减少CLP诱导的脓毒症小鼠模型中的心肌坏死以及TNF-α和IL-6的产生；减少外周CD4+和CD8+T细胞的数量并延长大鼠移植模型中的同种异体皮肤移植存活率。A tanshinone IIA derivative with immunomodulatory activity; reduces CSE-induced secretion of IL-6 and IL-8 and prevents CSE-induced decreases in CFTR levels in 16HBE cells; reduces lung function decline, mucus production, bronchial collagen deposition, and airspace enlargement in a mouse model of CS-induced COPD at 5 mg/kg; reduces myocardial necrosis and production of TNF-α and IL-6 in a mouse model of CLP-induced sepsis at 15 mg/kg; reduces the number of peripheral CD4+ and CD8+ T cells and prolongs allogeneic skin graft survival in a rat transplantation model.