Quazinone

一种选择性PDE3抑制剂，具有正性肌力和血管扩张作用；诱导预收缩的分离人海绵体平滑肌松弛(IC50=4.2μM)；在10-300μg/kg剂量依赖性地增加麻醉开胸犬的心肌收缩力，并降低收缩压和舒张压；以浓度依赖性方式抑制牛冠状动脉平滑肌细胞中PDGF-BB诱导的DNA合成。A selective PDE3 inhibitor with positive inotropic and vasodilating properties; induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM); increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner at 10-300 μg/kg, as well as decreases systolic and diastolic blood pressure; inhibits DNA synthesis induced by PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.