SMCC

一种异双功能交联剂，含有胺反应性N-羟基琥珀酰亚胺酯和巯基反应性马来酰亚胺基团，可用于蛋白质的结合；已用于将mertansine交联到IgG1单克隆抗体以形成抗体-药物偶联物DM1-SMCC；与用KLH和佐剂LPS免疫的小鼠相比，用SMCC偶联的海兔血蓝蛋白(KLH)抗原和同源脾细胞对小鼠进行免疫接种可增加从受体小鼠分离的脾细胞中增殖的T细胞的百分比。A heterobifunctional cross-linking reagent containing an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins; has been used to cross-link mertansine to an IgG1 monoclonal antibody to form the antibody-drug conjugate DM1-SMCC; immunization of mice with SMCC-coupled keyhole limpet hemocyanin (KLH) antigen and syngeneic splenocytes increases the percentage of proliferating T cells in isolated splenocytes from recipient mice compared to mice immunized with KLH and the adjuvant LPS.