GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.
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Yu, J., et al., Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity J. Biol. Chem.277 , 31441-31447, (2002)