- 询价
- Cell Signaling Technology
- 3153
- USA
- 2025年12月27日
- W, IHC-P
- H
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Progesterone Receptor A/B (C89F7) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Tyr541 of human progesterone receptor
- 应用范围：
W, IHC-P
- 适应物种：
H
- 供应商：
CST
- 库存：
大量
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IHC-P | H | Endogenous | 90 (PR-A) and 118 (PR-B) | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Progesterone Receptor A/B (C89F7) Rabbit mAb detects endogenous levels of total progesterone receptor A and B proteins. This antibody does not cross-react with other PR family members. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr541 of human progesterone receptor. Western Blotting
Western blot analysis of extracts from T47D cells using Progesterone Receptor A/B (C89F7) Rabbit mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Progesterone Receptor A/B (C89F1) Rabbit mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded T47D cells (positive, left) and MDA-MB-231 cells (negative, right) using Progesterone Receptor A/B (C89F1) Rabbit mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Progesterone Receptor A/B (C89F1) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). |
| Background | Human progesterone receptor (PR) is expressed as two forms: the full length PR B and the short form PR A. PR A lacks the first 164 amino acid residues of PR B (1,2). Both PR A and PR B are ligand activated but differ in their relative ability to activate target gene transcription (3,4). The activity of PR is regulated by phosphorylation; at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102 and Ser162) are unique to full length PR B while other sites (Ser190, Ser294, Ser345 and Ser400) are shared by both isoforms (5). Phosphorylation of PR B at Ser190 (equivalent to Ser26 of PR A) is catalyzed by CDK2 (6). Mutation of Ser190 results in decreased activity of PR (7), suggesting that the phosphorylation of Ser190 may be critical to its biological function.
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验h）即可。2. 修复大法——不仅仅是「煮一煮」微波炉修复：简单易行效果好，CST 推荐使用微波炉完成修复。合适的修复液：根据抗体说明书使用合适的修复液。用柠檬酸修复后，切片需浸泡在修复液中，自然冷却；而用 EDTA 修复后，切片可直接从修复缸中取出，直接进行下一步。注：使用不同的修复方式和不同生产商的抗体检测人肺癌组织中 EGFR 的表达。第一排为 CST 的 EGF Receptor (D38B1) XP® Rabbit mAb（#4267），EDTA 的修复方式明显优于柠檬酸盐及胃蛋白
four forward degenerate oligonucleotides (A, B, C, and D) that contained all the coding sequences for a conserved N glycosilation site of the GHR extracellular domain (LNWTLLNI) and four reverse degenerate oligonucleotides (E, F, G, and H) that contained
|998894|gb|S78179.1|S78179 Oryctolagus cuniculus type XII... 32 0.037 gi|31072033|gb|AC122153.4| Oryctolagus cuniculus clone LB1-... 28 0.58 gi|1496|emb|X52496.1|OCCAATP Rabbit mRNA for calcium ATPase 28 0.58 gi|1468|emb|X02814.1|OCATPDR Rabbit mRNA
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