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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 库存:
2
- 英文名:
p53 (17-26)
- CAS号:
p53 (17-26)
- 保质期:
1年
- 供应商:
北京孚博生物
- 保存条件:
2~8ºC保存
- 规格:
1mg
公司热衷于开发创新解决方案,以提供有助于改善生命科学和医疗保健的可持续产品和服务。Eurogentec目前已成为为生命科学研究、诊断和新疗法提供量身定制解决方案的世界领先供应商之一。公司持续将工作焦点放在开发创新的优质产品和服务, 致力于满足生命科学研究、诊断、治疗和制药领域科学家当前和未来的需求,并在全球范围内为他们提供高附加值的生物制品和化学品。
厂家官网:https://www.eurogentec.com/en/
我们优势进口日本Eurogentec的试剂,价格优惠,货期3-4周,质量和售后有保障!
了解更多产品和定制服务信息请留言,或 直接与我们销售人员联系。
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下面以分别以Eurogentec几种产品,来介绍Eurogentec的业务类型
①.Eurogentec提供各种多肽片段,以 p53 (17-26)为例:
产品信息:
This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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产品信息:
The sequence for the T7 Promoter universal primer is TAA TAC GAC TCA CTA TAG GG
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部分产品列表:
| 项目 | 内容 | 价格 | 品牌 |
| PCR | PCR Mixes dNTP Mix & Set DNA Polymerases Reverse transcriptase |
询价 | Eurogentec |
| qPCR | Takyon™ kits for Probe Assay Takyon™ kits for SYBR® Assay |
询价 | Eurogentec |
| RT-qPCR | Takyon™ qRT-PCR kits for Probe Assay Takyon™ One-step Kit Converter Kits selection tool |
询价 | Eurogentec |
| qPCR selector | qPCR & RT-qPCR additives ROX passive reference Fluorescein additive Uracil-N-Glycosylase (UNG) UNG-dUTP blend for carry-over prevention |
询价 | Eurogentec |
| Positive controls | Housekeeping controls Universal Exogenous qPCR Positive Control Sample Processing control |
询价 | Eurogentec |
| qPCR Plastics | Assay dispensing service for process automation | 询价 | Eurogen |
Eurogentec 目前作为一家一站式生物技术服务公司,除了提供现成的生物产品,如多肽片段,蛋白质,抗体,寡核苷酸片段等,Eurogentec还根据客户需求提供个性化生物技术服务,如根据用户需求制备某多/单克隆抗体,或目的基因分析等操作。目前,Eurogentec提供的所有服务可分为:
1. OLIGOS:根据用户需求创建引物,探针,siRNA等 Research Oligos
Track™ Oligos (high traceability)
Pre-Diagnostic & Diagnostic Oligos
ASR Oligos
Pre-Clinical & Therapeutic Oligos
CUSTOM OLIGOS
Backbones
Modifications
Purifications
Additional QC
Custom Format & Packaging
PROBES
Double-Dye Probes
Molecular Beacons
MGB Probes
Access Dyes & Quenchers
Design Assistance
RNAI
Custom siRNA Duplexes
siRNA Controls
miRNA Mimics & Inhibitors
Design Assistance
SPECIALIZED OLIGOS
NGS Oligos
Peptide-oligonucleotide conjugates
Complex Oligos
Large Scale Oligos
Oligo Aptamers
in vivo Oligos
REAGENTS
Universal Primers
Dye-labeled Calibration Oligos
PNA FISH Probes
Glen Synthesis Reagents
GMP *MANUFACTURING
Pre-Clinical & Therapeutic Oligos
GMP IVT-RNA Manufacturing
ORDER MY OLIGOS
Oligo Configurators
Oligo Batch Order
2.PCR&QPCR技术服务以及相关试剂提供:
ENDPOINT PCR
PCR Mixes
DNA Polymerases
Reverse Transcriptase
dNTP Mix & Set
QUANTITATIVE PCR KITS
qPCR Kits for Probe Assays
qPCR Kits for SYBR® Assays
Dried qPCR Kits for Probe Assays
QUANTITATIVE REVERSE TRANSCRIPTION PCR
One-Step Kits for Probe Assays
One-Step Kits for SYBR® Assays
One-Step Kit Converter
Two-Step Kits
Dried One-Step Kits for Probe Assays
CUSTOM MANUFACTURING
Tailored Amplification Reagents
Lab Developed Test Solutions
Kit Manufacturing
Custom housekeeping controls
PLATES & TUBES STRIPS
96-well plates
384-well Plates
8-tube Strips
Caps & Seals
CONTROLS
Catalog Housekeeping Controls
Custom housekeeping controls
Internal Positive Controls
Sample Processing Controls
ADDITIVES
ROX Passive Reference
Green Fluorescent Additive
Uracyl-N-Glycosylase (UNG)
UNG-dUTP blend for carry-over prevention
Blue Additive
IP FRIENDLY SOLUTIONS
Access Dyes & Quenchers
3.基因分析服务以及材料提供:
EXTRACTION/PURIFICATION
gDNA Extraction Kit
Plasmid Purification Kit
PCR Purification Kit
Gel DNA fragment Purification Kit
ELECTROPHORESIS SYSTEM
Mupid® -One device
LED Illuminator for Mupid®
Thin LED Illuminator
AGAROSE
Agarose Powder
AgaTabs (Agarose Tablet)
GMP *MANUFACTURING
GMP IVT RNA
GMP Plasmid DNA
TRANSFORMATION & TRANSFECTION
Electroporation Cuvettes
MOLECULAR WEIGHT LADDERS
Smart Ladders
Map*Marker®
CUSTOM MANUFACTURING
Custom Map*Marker®
4.免疫相关技术服务与抗体制备:
CUSTOM ANTIBODIES
Polyclonal Programs
Murine Hybridoma Development
Monoclonal in vitro Production
Animal Facilities
How to provide my antigen?
ANTIBODIES ADDITIONAL SERVICES
Pre-Immune selection of the host
Purifications
Labeling
ELISA testing
Fragmentation
Epitope Mapping
Antigen Design & Production
REAGENTS
Primary Antibodies
Secondary Antibodies
Protein A Conjugates
SOLUTIONS FOR THE INDUSTRY
Large scale Antibody Projects
GMP Antibody Fragments
GLP Studies
SPECIALIZED PROGRAMS
Camelid immunization & VHH production
VHH Ab Fragment
Chicken Immunization
Antibodies against Post Translational Modifications
5.多肽片段的制备与提供:
CUSTOM PEPTIDE SYNTHESIS
Custom Peptides
Quantified Peptides (Quant)
Heavy isotope-labeled Peptides
Fluorescent Labeled peptides
FRET Peptides
TR-FRET Peptides
Cyclic Peptides
Disulfide-Bridged Peptides
Stapled Peptides
Phosphorylated Peptides
Lipopeptides
Glycosylated and Glycated Peptides
Peptide-Oligonucleotide Conjugates
Peptide Libraries
CATALOG PEPTIDES
Neurosciences
Cardiovascular
Diabetes
Cancer & Apoptosis
Adhesion & Extracellular Matrix
Host Defense
Epigenetics
Hormones
Cell Signaling
Peptide & Protein Analysis
Cell Permeable and Penetrating Peptides
LABELING REAGENTS
Fluorescent Dyes
Quenchers
Biotin & Streptavidin derivatives
CRM MANUFACTURING
CRM peptides
6.特定蛋白质的提供,以及蛋白检测,标记等技术服务:
CUSTOM RECOMBINANT PROTEINS
RUO Grade Custom Production
GMP Recombinant Proteins
CATALOG RECOMBINANT PROTEINS
Neuroscience
Cardiovascular
Adhesion
Epigenetics
Viral Proteases & Sortase
Cell-free Protein Production
PROTEIN ANALYSIS
iD PAGE Gels
iD Molecular Weight Markers
iD BlueLadder Revealer
GMP* MANUFACTURING
GMP Recombinant Proteins
GMP Protein Conjugates
ASSAY KITS
Neuroscience
Cardiovascular Research
Cancer & Apoptosis
Adhesion & Extracellular Matrix
Epigenetics
Cell Biology & Protein Analysis
Host Defense
Diabetes
Cell Viability & Cytotoxicity
ELISA Kits
Enzyme Activity by Target
LABELING REAGENTS
Protein Labeling Kits
Biotin & Streptavidin derivatives
Protein Conjugates
Fluorescent labeling Dyes
Quenchers
Enzyme Substrates
Fluorescent Proteins
Neurological & Physiological Indicators
Nucleic Acid Detection
Calibration Standards
Hooke Laboratories:
SIGMA FBS胎牛血清常备库存:
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文献和实验【求助】P53的翻译后修饰都有哪些? 怎样验证其修饰后与靶标启动子的结合活性的变化?
可通过p53结合蛋白PRMT1和CARM1(辅助活化因子相关的精氨酸甲基转移酶)相互作用获得。当靶基因的转录激活不再需要p53时去乙酰化作用可以作为一种快速的调节机制来抑制p53的功能。 泛素化修饰 正常细胞中降解是消除p53功能的唯一机制,这种降解部分是由泛素-26S蛋白酶体系统完成的(其它途径是非泛素依赖性的)。泛素是一种高度保守的蛋白质,靶向作用于底物蛋白,使其被26S蛋白酶体降解成多肽。泛素连接酶实现了泛素化修饰的最后一步,这些酶显示出一种高水平的靶向特异性。正常
Stability and Ubiquitination of the Tumor Suppressor Protein p53
its recognition and rapid degradation by the 26S proteasome. The process of ubiquitination requires the concerted action of three classes of cellular enzymes, designated E1, E2, and E3 (reviewed in refs. 1 and 2 ). Ubiquitin is first activated in an ATP
Mutation of p53 Tumor Suppressor Gene in Hepatocellular Carcinoma
In recent years, the most commonly observed genetic alteration in hepatocellular carcinoma (HCC), as in many other tumors affecting man, has been reported to be the mutation of the p53 coding gene (1 ,2 ). This gene has the features











