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多肽片段 p53 (17-26)

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  • 询价
  • Eurogentec
  • p53 (17-26)
  • 日本
  • 2025年08月24日
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 库存

      2

    • 英文名

      p53 (17-26)

    • CAS号

      p53 (17-26)

    • 保质期

      1年

    • 供应商

      北京孚博生物

    • 保存条件

      2~8ºC保存

    • 规格

      1mg

    Eurogentec 于 1985 年从列日大学 (BE) 分拆出来,于2010 年成为日本国际化学公司 Kaneka Corporation 的成员。从那时起,该公司开发了专有工艺并继续扩大投资,为世界各地的科学家提供尖端产品。Eurogentec 目前作为一家一站式生物技术服务公司,为全球学术、医学和工业科学家提供生命科学产品和个性化服务。Eurogentec还是一家值得信赖的 CDMO,在生物制药关键原材料和治疗分子的开发和生产方面得到国际认可。
    公司热衷于开发创新解决方案,以提供有助于改善生命科学和医疗保健的可持续产品和服务。Eurogentec目前已成为为生命科学研究、诊断和新疗法提供量身定制解决方案的世界领先供应商之一。公司持续将工作焦点放在开发创新的优质产品和服务, 致力于满足生命科学研究、诊断、治疗和制药领域科学家当前和未来的需求,并在全球范围内为他们提供高附加值的生物制品和化学品。

    厂家官网:https://www.eurogentec.com/en/

    我们优势进口日本Eurogentec的试剂,价格优惠,货期3-4周,质量和售后有保障!

    了解更多产品和定制服务信息请留言,或 直接与我们销售人员联系。
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    下面以分别以Eurogentec几种产品,来介绍Eurogentec的业务类型
    ①.Eurogentec提供各种多肽片段,以 p53 (17-26)为例:
    产品信息:
    This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development.
    Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
    产品参数:
    Chemistry
    Sequence one letter code
    • ETFSDLWKLL
    Sequence three letter code
    • H-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-OH
    Molecular Formula
    • C60H90N12O17
    Molecular Mass/ Weight
    • 1251.5
    Modification
    Conjugation
    • Unconjugated
    Quantity & Purity
    Purity  
    Storage & stability
    Form
    • Lyophilized
    Storage Conditions
    • - 20 °C
    Activity
    Biomarker Target
    Research Area
    Sub-category Research Area
    Usage
    • Research use
    Source
    Source / Species
    • human
    Codes
    Code Nacres
    • NA.26
    . Eurogentec能够根据用户需求设计特定核苷酸片段,此外公司旗下也有多种现成的片段,这里以T7 Promoter为例:
    产品信息:
    The sequence for the T7 Promoter universal primer is TAA TAC GAC TCA CTA TAG GG
    产品参数:
    Packaging
    Kits components
    • 1 x 2ml tube containing 5 nmol of universal primer
    Chemistry
    Sequence one letter code
    • 5' TAA TAC GAC TCA CTA TAG GG 3'
    Molecular Mass/ Weight
    • 6125.00 g/mol
    Quantity & Purity
    Purification Method
    • RP-HPLC
    Storage & stability
    Form
    • Dried
    Resuspension condition
    • To make up to 100 µM concentration, add 50 µl of recommended buffer. To make up to 20 µM concentration, add 250 µl of recommended buffer. To make up to 5 µM concentration, add 1000 µl of recommended buffer.
    Storage Conditions
    • Dried Oligonucleotides are stable for 18 months at ambiant temperature. For more information please refer to the Reconstitution-Storage-Stability page
    Activity
    Usage
    • Research use
    Codes
    Code Nacres
    • NA.51

    部分产品列表:
    项目 内容 价格 品牌
    PCR PCR Mixes
    dNTP Mix & Set
    DNA Polymerases
    Reverse transcriptase
    询价 Eurogentec
    qPCR Takyon™ kits for Probe Assay
    Takyon™ kits for SYBR® Assay
    询价 Eurogentec
    RT-qPCR Takyon™ qRT-PCR kits for Probe Assay
    Takyon™ One-step Kit Converter
    Kits selection tool
    询价 Eurogentec
    qPCR selector qPCR & RT-qPCR additives
    ROX passive reference
    Fluorescein additive
    Uracil-N-Glycosylase (UNG)
    UNG-dUTP blend for carry-over prevention
    询价 Eurogentec
    Positive controls Housekeeping controls
    Universal Exogenous qPCR Positive Control
    Sample Processing control
    询价 Eurogentec
    qPCR Plastics Assay dispensing service for process automation 询价 Eurogen


    Eurogentec 目前作为一家一站式生物技术服务公司,除了提供现成的生物产品,如多肽片段,蛋白质,抗体,寡核苷酸片段等,Eurogentec还根据客户需求提供个性化生物技术服务,如根据用户需求制备某多/单克隆抗体,或目的基因分析等操作。目前,Eurogentec提供的所有服务可分为:
    1. OLIGOS:根据用户需求创建引物,探针,siRNA等 Research Oligos
    Track Oligos (high traceability)
    Pre-Diagnostic & Diagnostic Oligos
    ASR Oligos
    Pre-Clinical & Therapeutic Oligos
    CUSTOM OLIGOS
    Backbones
    Modifications
    Purifications
    Additional QC
    Custom Format & Packaging
    PROBES
    Double-Dye Probes
    Molecular Beacons
    MGB Probes
    Access Dyes & Quenchers
    Design Assistance

    RNAI
    Custom siRNA Duplexes
    siRNA Controls
    miRNA Mimics & Inhibitors
    Design Assistance
    SPECIALIZED OLIGOS
    NGS Oligos
    Peptide-oligonucleotide conjugates
    Complex Oligos
    Large Scale Oligos
    Oligo Aptamers
    in vivo Oligos
    REAGENTS
    Universal Primers
    Dye-labeled Calibration Oligos
    PNA FISH Probes
    Glen Synthesis Reagents
    GMP *MANUFACTURING
    Pre-Clinical & Therapeutic Oligos
    GMP IVT-RNA Manufacturing
    ORDER MY OLIGOS
    Oligo Configurators
    Oligo Batch Order

    2.PCR&QPCR技术服务以及相关试剂提供:
    ENDPOINT PCR
    PCR Mixes
    DNA Polymerases
    Reverse Transcriptase
    dNTP Mix & Set
    QUANTITATIVE PCR KITS
    qPCR Kits for Probe Assays
    qPCR Kits for SYBR® Assays
    Dried qPCR Kits for Probe Assays
    QUANTITATIVE REVERSE TRANSCRIPTION PCR
    One-Step Kits for Probe Assays
    One-Step Kits for SYBR® Assays
    One-Step Kit Converter
    Two-Step Kits
    Dried One-Step Kits for Probe Assays
    CUSTOM MANUFACTURING
    Tailored Amplification Reagents
    Lab Developed Test Solutions
    Kit Manufacturing
    Custom housekeeping controls
    PLATES & TUBES STRIPS
    96-well plates
    384-well Plates
    8-tube Strips
    Caps & Seals
    CONTROLS
    Catalog Housekeeping Controls
    Custom housekeeping controls
    Internal Positive Controls
    Sample Processing Controls
    ADDITIVES
    ROX Passive Reference
    Green Fluorescent Additive
    Uracyl-N-Glycosylase (UNG)
    UNG-dUTP blend for carry-over prevention
    Blue Additive
    IP FRIENDLY SOLUTIONS
    Access Dyes & Quenchers
    3.基因分析服务以及材料提供:
    EXTRACTION/PURIFICATION
    gDNA Extraction Kit
    Plasmid Purification Kit
    PCR Purification Kit
    Gel DNA fragment Purification Kit
    ELECTROPHORESIS SYSTEM
    Mupid® -One device
    LED Illuminator for Mupid®
    Thin LED Illuminator
    AGAROSE
    Agarose Powder
    AgaTabs (Agarose Tablet)
    GMP *MANUFACTURING
    GMP IVT RNA
    GMP Plasmid DNA
    TRANSFORMATION & TRANSFECTION
    Electroporation Cuvettes
    MOLECULAR WEIGHT LADDERS
    Smart Ladders
    Map*Marker®
    CUSTOM MANUFACTURING
    Custom Map*Marker®
    4.免疫相关技术服务与抗体制备:
    CUSTOM ANTIBODIES
    Polyclonal Programs
    Murine Hybridoma Development
    Monoclonal in vitro Production
    Animal Facilities
    How to provide my antigen?
    ANTIBODIES ADDITIONAL SERVICES
    Pre-Immune selection of the host
    Purifications
    Labeling
    ELISA testing
    Fragmentation
    Epitope Mapping
    Antigen Design & Production
    REAGENTS
    Primary Antibodies
    Secondary Antibodies
    Protein A Conjugates
    SOLUTIONS FOR THE INDUSTRY
    Large scale Antibody Projects
    GMP Antibody Fragments
    GLP Studies
    SPECIALIZED PROGRAMS
    Camelid immunization & VHH production
    VHH Ab Fragment
    Chicken Immunization
    Antibodies against Post Translational Modifications
    5.多肽片段的制备与提供:
    CUSTOM PEPTIDE SYNTHESIS
    Custom Peptides
    Quantified Peptides (Quant)
    Heavy isotope-labeled Peptides
    Fluorescent Labeled peptides
    FRET Peptides
    TR-FRET Peptides
    Cyclic Peptides
    Disulfide-Bridged Peptides
    Stapled Peptides
    Phosphorylated Peptides
    Lipopeptides
    Glycosylated and Glycated Peptides
    Peptide-Oligonucleotide Conjugates
    Peptide Libraries
    CATALOG PEPTIDES
    Neurosciences
    Cardiovascular
    Diabetes
    Cancer & Apoptosis
    Adhesion & Extracellular Matrix
    Host Defense
    Epigenetics
    Hormones
    Cell Signaling
    Peptide & Protein Analysis
    Cell Permeable and Penetrating Peptides
    LABELING REAGENTS
    Fluorescent Dyes
    Quenchers
    Biotin & Streptavidin derivatives
    CRM MANUFACTURING
    CRM peptides
    6.特定蛋白质的提供,以及蛋白检测,标记等技术服务:
    CUSTOM RECOMBINANT PROTEINS
    RUO Grade Custom Production
    GMP Recombinant Proteins
    CATALOG RECOMBINANT PROTEINS
    Neuroscience
    Cardiovascular
    Adhesion
    Epigenetics
    Viral Proteases & Sortase
    Cell-free Protein Production
    PROTEIN ANALYSIS
    iD PAGE Gels
    iD Molecular Weight Markers
    iD BlueLadder Revealer
    GMP* MANUFACTURING
    GMP Recombinant Proteins
    GMP Protein Conjugates
    ASSAY KITS
    Neuroscience
    Cardiovascular Research
    Cancer & Apoptosis
    Adhesion & Extracellular Matrix
    Epigenetics
    Cell Biology & Protein Analysis
    Host Defense
    Diabetes
    Cell Viability & Cytotoxicity
    ELISA Kits
    Enzyme Activity by Target
    LABELING REAGENTS
    Protein Labeling Kits
    Biotin & Streptavidin derivatives
    Protein Conjugates
    Fluorescent labeling Dyes
    Quenchers
    Enzyme Substrates
    Fluorescent Proteins
    Neurological & Physiological Indicators
    Nucleic Acid Detection
    Calibration Standards


    产品细节图片1    产品细节图片2  

    Hooke Laboratories:  产品细节图片3   产品细节图片4
    产品细节图片5  

    SIGMA FBS胎牛血清常备库存:
    产品细节图片6   产品细节图片7


     

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    • 作者
    • 内容
    • 询问日期
    图标文献和实验
    相关实验
    • 【求助】P53的翻译后修饰都有哪些? 怎样验证其修饰后与靶标启动子的结合活性的变化?

      可通过p53结合蛋白PRMT1和CARM1(辅助活化因子相关的精氨酸甲基转移酶)相互作用获得。当靶基因的转录激活不再需要p53时去乙酰化作用可以作为一种快速的调节机制来抑制p53的功能。 泛素化修饰 正常细胞中降解是消除p53功能的唯一机制,这种降解部分是由泛素-26S蛋白酶体系统完成的(其它途径是非泛素依赖性的)。泛素是一种高度保守的蛋白质,靶向作用于底物蛋白,使其被26S蛋白酶体降解成多肽。泛素连接酶实现了泛素化修饰的最后一步,这些酶显示出一种高水平的靶向特异性。正常

    • Stability and Ubiquitination of the Tumor Suppressor Protein p53

      its recognition and rapid degradation by the 26S proteasome. The process of ubiquitination requires the concerted action of three classes of cellular enzymes, designated E1, E2, and E3 (reviewed in refs. 1 and 2 ). Ubiquitin is first activated in an ATP

    • Mutation of p53 Tumor Suppressor Gene in Hepatocellular Carcinoma

      In recent years, the most commonly observed genetic alteration in hepatocellular carcinoma (HCC), as in many other tumors affecting man, has been reported to be the mutation of the p53 coding gene (1 ,2 ). This gene has the features

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