Upon receipt, please store the beads at -20°C for 1 year in lyophilized state. Please avoid more than 3 freeze-thaw cycles. Immediate use after reconstitution is highly recommended.
英文名:
Human CD3E-coupled Magnetic Beads
库存:
1///2
供应商:
ACROBiosystems
规格:
2mg/10mg
规格:
2mg
产品价格:
¥8000.0
规格:
10mg
产品价格:
¥25000.0
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.