Inarigivir,2172788-92-8

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Inarigivir ammonium

CAS No. : 2172788-92-8

MCE 国际站：Inarigivir ammonium

产品活性：Inarigivir (ORI-9020) ammonium 是一种二核苷酸抗病毒化合物，可显着减少表达乙型肝炎病毒转基因小鼠的 HBV DNA。Inarigivir (ORI-9020) 是维甲酸诱导基因-I (RIG-I) 的激动剂，可激活细胞内的先天免疫。

研究领域：Anti-infection

作用靶点：HBV

In Vitro: Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B.

In Vivo: Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values.

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