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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
G1T48
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2088518-51-6
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5500.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2000.0 |
| 规格： | 5 mg | 产品价格： | ￥5000.0 |
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Rintodestrant
CAS No. : 2088518-51-6
MCE 国际站：Rintodestrant
产品活性：Rintodestrant (G1T48) 是具有口服活性的、非甾体类的、选择性的雌激素受体 (estrogen receptor) 的降解剂。Rintodestrant (G1T48) 也是 CDK4/6 的抑制剂。
研究领域：Vitamin D Related/Nuclear Receptor | Cell Cycle/DNA Damage
作用靶点：Estrogen Receptor/ERR | CDK
In Vitro: Rintodestrant (G1T48) is a potent and efficacious inhibitor of estrogen-mediated transcription and proliferation in ER-positive breast cancer cells, similar to the pure antiestrogen fulvestrant.
Rintodestrant (G1T48) selectively inhibits the growth of ER-positive, but not ER-negative, breast cancer cells.
In Vivo: Rintodestrant (G1T48, 30 or 100 mg/kg) inhibits estrogen signaling in endocrine-resistant breast cancer models.
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