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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
- 英文名：
Interferon alpha-4;Interferon alpha-4B;Interferon alpha-76;Interferon alpha-M1;IFNA4
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 μg/50 μg
| 规格： | 10 μg | 产品价格： | ￥1520.0 |
|---|---|---|---|
| 规格： | 50 μg | 产品价格： | ￥4000.0 |
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IFN-alpha 4/IFNA4 Protein, Human (HEK293, His)
MCE 国际站：IFN-alpha 4/IFNA4 Protein, Human (HEK293, His)
IFN-alpha 4 (IFNA4) 属于 I 型干扰素家族，由巨噬细胞产生而具有抗病毒活性。重组人 IFN-alpha 4/IFNA4 蛋白 (HEK293, His) 含有 166 个氨基酸 (C24-D189)，由 HEK293 细胞产生并带有 C 端 His 标签。
Synonyms: Interferon alpha-4; Interferon alpha-4B; Interferon alpha-76; Interferon alpha-M1; IFNA4
Species: Human
Source: HEK293
研究背景：IFN-alpha 4 (IFNA4; IFN-α4), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
IFN-alpha 4 is the subtypes dominates in IFN-alpha, whose the response with IFNA5, IFNA7, and IFNA14 accounting for up to 85% of the subtypes expressed by Peripheral blood mononuclear cells (PBMCs).
IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7. And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus.
As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA4 protein of human is very different from mouse (57.07%) and rat (57.98), respectively.
蛋白编号：P05014 (C24-D189)
基因 ID：3441
产品分类：细胞因子和生长因子 | 干扰素 | 干扰素 α | 干扰素 α4
Categories：Cytokines and Growth Factors | Interferon & Receptors | IFN-alpha | IFN-alpha 4
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文献和实验【求助】矛盾的实验结果：IKb alpha和NFKB同时升高
吴佰霖 我的基因过表达，结合文献，推理应该是IKb alpha下降，而NFKB升高 （IKb可磷酸化NFKB，使后者降低） 但现在我的结果是两者同时升高，请问可能的原因有哪些呢？ 谢谢 woxingwosu 可否检测一下NFKB的磷酸化情况？ erik NFKB是检测核内的吗？检测p65还是p50/ 吴佰霖 检测总蛋白
ALPHA FACTOR ARREST AND RELEASE
of approximately 3 x 10�5 M, while bar1 strains require much lower pheromone concentrations (10-8 M). To release cells from alpha factor arrest, spin down cells and wash twice (using a large volume, dependent on the size of the cell pellet anticipated
LABELING ALPHA-ACTININ WITH IATR
with good stirring.The volume (ml)of borate buffer = mg IATR x 9 / (mg/ml)alpha-actinin. 4.Clarify IATR solution at 25,000 rpm,4℃,for 10 min in a 42.2Ti rotor. 5.Mix equal volumes of clarified dye and alpha-actinin in a test tube; remove
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