IPAG,193527-91-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IPAG

CAS No. : 193527-91-2

MCE 国际站：IPAG

产品活性：IPAG 是一种有效的 sigma-1 受体拮抗剂，pK_i 为 4.3。 IPAG 可诱导细胞凋亡 (apoptosis)。

研究领域：Neuronal Signaling

作用靶点：Sigma Receptor

In Vitro: Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells.
IPAG treatment produces a mean of 100±8 μg per 10⁶ cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass.
IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1.

相关产品：Bioactive Compound Library Plus  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Anti-Breast Cancer Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  BD-1047 dihydrobromide  |  PRE-084 hydrochloride  |  S1RA hydrochloride  |  Cutamesine dihydrochloride  |  Blarcamesine hydrochloride  |  (±)-Vesamicol hydrochloride  |  CT1812  |  Dimemorfan phosphate  |  Roluperidone  |  σ1 Receptor antagonist-1  |  Siramesine hydrochloride  |  BD1063 dhydrochloride  |  Glycerol phenylbutyrate  |  CM398  |  PB28 dihydrochloride  |  Blonanserin  |  PD 144418  |  NE-100 hydrochloride  |  Pentoxyverine  |  Ditolylguanidine  |  Rimcazole dihydrochloride  |  BMY-14802 hydrochloride  |  Panamesine  |  SKF 83959  |  SR-31747  |  Sigma-LIGAND-1  |  4-IBP

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds