Vornorexant,1517965-94-4

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Vornorexant

CAS No. : 1517965-94-4

MCE 国际站：Vornorexant

产品活性：Vornorexant (ORN-0829; TS-142) 是一种有效的 OX1R 和 OX2R 双拮抗剂，IC₅₀ 值分别为 1.05 nM 和 1.27 nM。Vornorexant 在动物模型中表现出有效的睡眠促进作用，可作用于研究失眠。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Orexin Receptor (OX Receptor)

In Vivo: Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep.
Vornorexant exhibits optimal PK properties with a rapid T_max and short half-lives in rats and dogs. The T_1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog.

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