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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CTP-543; Ruxolitinib d<sub>8</sub>; Deuterated Ruxolitinib
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1513883-39-0
- 规格：
1 mg
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Deuruxolitinib
CAS No. : 1513883-39-0
MCE 国际站：Deuruxolitinib
产品活性：Deuruxolitinib，是一种氘代的 Ruxolitinib，可调节 JAK1/JAK2 的活性。Deuruxolitinib 可用于研究脱发疾病 (详细信息来自专利 WO2017192905A1，compound I)。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：JAK
In Vitro: "Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Potential advantages of deuterated compounds:
(1) Extend the half-life in vivo. Deuterated compounds may be able to prolong the pharmacokinetic characteristics of the compound, that is, prolong the half-life in vivo. This can improve compound safety, efficacy and tolerability, and increase ease of administration.
(2) Improve oral bioavailability. Deuterated compounds may reduce the degree of unwanted metabolism (first-pass metabolism) in the gut wall and liver, allowing a greater proportion of the unmetabolized drug to reach its target site of action. High bioavailability determines its activity at low doses and better tolerance.
(3) Improve metabolic characteristics. Deuterated compounds may reduce the formation of toxic or reactive metabolites and improve drug metabolism.
(4) Improve drug safety. Deuterated compounds may reduce or eliminate adverse side effects of pharmaceutical compounds and are safe.
(5) Preserve the therapeutic properties. Deuterated compounds are expected to retain similar biochemical potency and selectivity to hydrogen analogs in previous studies.
"
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文献和实验。 -------------------------------------------------------------------------------- 请去掉连接中的“-”再输入地址栏下载。我也不想这样···战里就是要屏蔽他的嘛！ 也可以到http://cdsg.bokee.com/6473220.html下载 GenesVIII.chm (27.63MB) [下载] http://m39.mail.q-q-.c-o-m/cgi-bin/exs_download?uin
，这样才能实现程序降温呢? 时间使用长了，感觉里面的液体是不是异丙醇啊，使用时间长了会不会挥发或变质什么的，要不要添加或维护一下呢，还有有一只降温盒因不小心给倾斜让液体流出了部分，要补充吗? 经验1：冻存盒外表面有刻度的吧，异丙醇液面要高于最底线。4 a. C* D8 Y& P9 A, y 冻存盒肯定是先放在室温，然后放进去细胞，置于-80，利用异丙醇实现梯度降温啊。) ~0 O( O# Q* }: w# D" R' _ 根据论坛里的讨论，异丙醇使用过一段
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