Norathyriol芒果苷元,3542-72-1

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Norathyriol

CAS No. : 3542-72-1

MCE 国际站：Norathyriol

产品活性：Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase )，IC₅₀ 为 3.12 μM。Norathyriol 还抑制 PPARα、PPARβ 和 PPARγ，IC₅₀ 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor  |  Cell Cycle/DNA Damage

作用靶点：Glucosidase  |  PPAR

In Vitro: Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest.
Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cellsCell Growth Assay WB

In Vivo: Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety.
Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively.

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