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Gli1

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  • ¥1125 - 1875
  • HuaBio/华安生物
  • 华安生物
  • 2025年07月12日
  • WB, ICC, IHC-P
  • Rabbit
  • Human, Mouse, Rat
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide within Human Gli1 aa 38-82 / 1106.

    • 亚型

      IgG

    • 形态

      Liquid

    • 克隆性

      Recombinant Rabbit monoclonal Antibody

    • 标记物

      Non-conjugated

    • 适应物种

      Human, Mouse, Rat

    • 库存

      现货

    • 供应商

      华安生物

    • 宿主

      Rabbit

    • 应用范围

      WB, ICC, IHC-P

    • 浓度

      1 mg/mL.

    • 规格

      50μl/100μl

    规格:50μl产品价格:¥1125.0
    规格:100μl产品价格:¥1875.0
    Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-1 (GLI family zinc finger 1), also known as Glioma-associated oncogene or oncogene GLI, is a 1,106 amino acid protein that localizes to both the cytoplasm and nucleus, and belongs to the GLI C2H2-type zinc-finger protein family. GLI-1 acts as a transcriptional activator and is thought to play a role in craniofacial development. GLI-1 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 12q13.3.

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    图标文献和实验
    相关实验
    • Cancer Immunol Res:石敏团队揭示重塑基质代谢 - 免疫排斥微环境改善 MSS 型结直肠癌免疫治疗疗效

      Cancer with Microsatellite Stability 的研究论文。 该项研究证明了在 MSS 型结直肠癌中存在一种与预后不良相关的基质代谢-免疫排斥亚型,其特征是 6-硫酸软骨素(C-6-S)代谢物与 M2 巨噬细胞相互作用,在浸润边缘形成「排斥屏障」。 具体来讲,肿瘤相关成纤维细胞来源的 C-6-S 促进 pSTAT3 和 GLI1 的核共定位,激活 JAK/STAT3 和 Hedgehog 通路,从而诱导巨噬细胞向 M2 极化,导致 TME 免疫排斥;体内靶向 C-6-S

    • Efficient Manipulation of Hedgehog/GLI Signaling Using Retroviral Expression Systems

      systems as a valuable tool to activate or repress Hh-pathway activity in a broad spectrum of mammalian cells—including human cells—either by forced expression of the major Hedgehog-effectors GLI1 and GLI2 or by expression of the short-hairpin RNAs

    • 细胞信号通路相关文献

      -1 cells were treated with different concentrations of curcumin (10, 20 and 30 μmol/ml) for 48 h. The growth inhibition rate of the cells was measured by MTT assay, apoptosis was detected by flow cytometry, the expression levels of Shh, GLI1, E-cadherin

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