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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Synthetic peptide within Human Gli1 aa 38-82 / 1106.
- 亚型:
IgG
- 形态:
Liquid
- 克隆性:
Recombinant Rabbit monoclonal Antibody
- 标记物:
Non-conjugated
- 适应物种:
Human, Mouse, Rat
- 库存:
现货
- 供应商:
华安生物
- 宿主:
Rabbit
- 应用范围:
WB, ICC, IHC-P
- 浓度:
1 mg/mL.
- 规格:
50μl/100μl
| 规格: | 50μl | 产品价格: | ¥1125.0 |
|---|---|---|---|
| 规格: | 100μl | 产品价格: | ¥1875.0 |
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文献和实验Cancer Immunol Res:石敏团队揭示重塑基质代谢 - 免疫排斥微环境改善 MSS 型结直肠癌免疫治疗疗效
Cancer with Microsatellite Stability 的研究论文。 该项研究证明了在 MSS 型结直肠癌中存在一种与预后不良相关的基质代谢-免疫排斥亚型,其特征是 6-硫酸软骨素(C-6-S)代谢物与 M2 巨噬细胞相互作用,在浸润边缘形成「排斥屏障」。 具体来讲,肿瘤相关成纤维细胞来源的 C-6-S 促进 pSTAT3 和 GLI1 的核共定位,激活 JAK/STAT3 和 Hedgehog 通路,从而诱导巨噬细胞向 M2 极化,导致 TME 免疫排斥;体内靶向 C-6-S
Efficient Manipulation of Hedgehog/GLI Signaling Using Retroviral Expression Systems
systems as a valuable tool to activate or repress Hh-pathway activity in a broad spectrum of mammalian cells—including human cells—either by forced expression of the major Hedgehog-effectors GLI1 and GLI2 or by expression of the short-hairpin RNAs
-1 cells were treated with different concentrations of curcumin (10, 20 and 30 μmol/ml) for 48 h. The growth inhibition rate of the cells was measured by MTT assay, apoptosis was detected by flow cytometry, the expression levels of Shh, GLI1, E-cadherin
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