Recombinant protein with Human IGF1R aa 627-952 / 1,367.
亚型:
IgG
形态:
Liquid
克隆性:
Rabbit polyclonal Antibody
标记物:
Non-conjugated
适应物种:
Human
库存:
现货
供应商:
华安生物
宿主:
Rabbit
应用范围:
WB, IHC-P
浓度:
1 mg/mL.
规格:
50ul/100ul
规格:
50ul
产品价格:
¥1125.0
规格:
100ul
产品价格:
¥1875.0
Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.