Synthetic peptide corresponding to Human N-Cadherin aa 391-440 / 906 (H412G).
亚型:
IgG
形态:
Liquid
克隆性:
Rabbit polyclonal Antibody
标记物:
Non-conjugated
适应物种:
Human, Mouse
库存:
现货
供应商:
华安生物
宿主:
Rabbit
应用范围:
WB, ICC, IHC-P, FC
浓度:
1 mg/mL.
抗体名:
N-Cadherin
规格:
50μl/100μl
规格:
50μl
产品价格:
¥1125.0
规格:
100μl
产品价格:
¥1875.0
The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which phosphorylates beta-catenins attached to both N-cadherin (this protein) and E-cadherins.