Recombinant protein within Human Frizzled 8 aa 561-694 / 694.
亚型:
IgG
形态:
Liquid
克隆性:
Recombinant Rabbit monoclonal Antibody
标记物:
Non-conjugated
适应物种:
Human, Mouse
库存:
现货
供应商:
华安生物
宿主:
Rabbit
应用范围:
WB,IHC-P
浓度:
1 mg/mL.
规格:
50ul/100ul
规格:
50ul
产品价格:
¥1125.0
规格:
100ul
产品价格:
¥1875.0
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.