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CTCF

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  • ¥1125 - 1875
  • HuaBio/华安生物
  • 华安生物
  • ET1703-90
  • 2025年07月15日
  • WB, ICC/IF, IHC-P, IP,FC
  • Rabbit
  • Human, Mouse, Zebrafish
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide within Human CTCF aa 685-727 / 727.

    • 亚型

      IgG

    • 形态

      Liquid

    • 克隆性

      Recombinant Rabbit monoclonal Antibody

    • 标记物

      Non-conjugated

    • 适应物种

      Human, Mouse, Zebrafish

    • 库存

      现货

    • 供应商

      华安生物

    • 宿主

      Rabbit

    • 应用范围

      WB, ICC/IF, IHC-P, IP,FC

    • 浓度

      1 mg/mL.

    • 规格

      50μl/100μl

    规格:50μl产品价格:¥1125.0
    规格:100μl产品价格:¥1875.0
    CTCF belongs to the zinc finger transcription factor family, and it recognizes unusually long and remarkably divergent DNA target sequences to influence expression of many various genes. The DNA-binding domain of CTCF is composed of 11 Zn fingers including 10 that are of C2H2 class, and 1 that is of C2HC class, and they are highly conserved between vertebrate species. CTCF functions as a repressor of the c-myc gene and as a regulator of lysozyme gene expression. In addition, CTCF associates with the essential activator domain in the promotor region of the amyloid beta-protein precursor (APP) gene to activate transcription of APP. Expression of CTCF up-regulates APP expression and thereby, enhances synapse formations between primary neurons during development. CTCF is ubiquitously expressed and localized to the nucleus. During terminal differentiation, CTCF is negatively regulated by differential phosphorylation and also by decreases in CTCF mRNA and protein expression.

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    图标文献和实验
    相关实验
    • Generation of Poly(ADP-ribosyl)ation Deficient Mutants of the Transcription Factor, CTCF

      to produce such mutants, demonstrated by the example of CTCF, a transcription factor. To achieve this in our study, the protein domain modified by PARylation was mapped and the amino acids, which can be potentially PARylated, selected. Mutations

    • DNA 甲基化检测与肿瘤的那些事儿

      聚集成 CpG 岛(CCIs),50% 以上的基因启动子都含 CCIs,一般都集中在转录起始位点。甲基的存在导致了转录过程终止,从而使这些基因沉默。其机制主要与转录因子 CTCF(CCCTC binding factor)蛋白和甲基 CpG 结合蛋白(MBP)有关。CTCF 可以控制染色质三维结构的改变,促进或抑制不同位点的基因表达,但 CTCF 不能与甲基化CpG 结合,MBP 含有甲基化 CpGs 结合域,同时能与组蛋白去乙酰化酶(HDAC)结合,可重构染色质并抑制转录。 图

    • 用RNAi研究基因组印迹现象的调控机制

      their findings in the January 9, 2004, issue of the journal Science. The researchers sought to pinpoint the regulatory role of a protein known as CTCF, which is believed to attach to a control region near imprinted genes. By binding to this region

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