Synthetic peptide within Human Caspase-3 aa 18-67 / 277.
亚型:
IgG
形态:
Liquid
克隆性:
Recombinant Rabbit monoclonal Antibody
标记物:
Non-conjugated
适应物种:
Human
库存:
现货
供应商:
华安生物
宿主:
Rabbit
应用范围:
WB, ICC/IF, IHC-P
浓度:
1 mg/mL.
规格:
50μl/100μl
规格:
50μl
产品价格:
¥1125.0
规格:
100μl
产品价格:
¥1875.0
Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system.