KG19

BRI3BP (BRI3 binding protein) is an oncogene, which is a HCCR (human cervical cancer)-interacting protein, and is also called HCCRBP-1. This protein is composed of 166 amino acids, and has a molecular weight of 19kDa. It is also called BASH N-terminus-associated protein 1 (BNAS1), and contains four putative transmembrane regions and a leucine-zipper. It has a ubiquitous expression pattern. It resides in the endoplasmic reticulum. BRI3BP (BRI3 binding protein) is an oncogene, which is up-regulated in multiple tumors. It induces protein kinase C (PKC) activities, while suppressing the function of PKCδ and PKCα isoforms, which are pro-apoptotic in nature. It also stabilizes p53 gene, thus promoting tumorigenesis. It interacts with BASH/BLNK (B-cell linker)/SLP-65 protein, at the N-terminal, at the membrane of either endoplasmic reticulum (ER) or nucleus. It activates Elk-1, by regulation of the signaling pathway through mitogen-activated protein kinase (MAPK). It also affects the ER structural dyamics, as well as regulates mitochondrial viability.