- ￥1125 - 1875
- HuaBio/华安生物
- 华安生物
- ER62033
- 2025年10月31日
- WB
- Rabbit
- Human, Rat, Mouse
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- 详细信息
- 技术资料
- 免疫原：
Synthesized peptide derived from human protein . at AA range: 100-180
- 亚型：
IgG
- 形态：
Liquid
- 克隆性：
Rabbit polyclonal Antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Rat, Mouse
- 库存：
现货
- 供应商：
华安生物
- 宿主：
Rabbit
- 应用范围：
WB
- 浓度：
1 mg/mL.
- 规格：
50μl/100μl
| 规格： | 50μl | 产品价格： | ￥1125.0 |
|---|---|---|---|
| 规格： | 100μl | 产品价格： | ￥1875.0 |
Unessential component of the TORC1 complex and essential component of the TORC2 complex. TORC1 controls cell growth in response to environmental signals, and is inactivated by nutrient limitation and environmental stress. Within TORC1, LST8 interacts directly with FRAP1 and enhances its kinase activity. In nutrient-poor conditions, stabilizes the FRAP1-RAPTOR interaction and favors RAPTOR-mediated inhibition of FRAP1 activity. TORC2 controls polarity of the actin cytoskeleton via the RAC1 pathway. TORC2 mediates phosphorylation of Akt/PKB on 'Ser-473' and phosphorylation of PKCalpha on 'Ser-657'. Belongs to the WD repeat LST8 family. Contains 7 WD repeats. subunit:Interacts with FRAP1, RAPTOR and RHEB. Part of the target of rapamycin complex 1 (TORC1) which contains LST8, FRAP1, RAPTOR and AKT1S1. TORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the target of rapamycin complex 2 (TORC2) which contains FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
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LST8
￥1125 - 1875
