- ￥1125 - 1875
- HuaBio/华安生物
- 华安生物
- ER1914-72
- 2025年10月16日
- WB, FC
- Rabbit
- Human, Mouse, Rat, Pig, Cow
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- 详细信息
- 技术资料
- 免疫原：
KLH conjugated synthetic peptide derived from human PALB2 1101-1186/1186
- 亚型：
IgG
- 形态：
Liquid
- 克隆性：
Rabbit polyclonal Antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat, Pig, Cow
- 库存：
现货
- 供应商：
华安生物
- 宿主：
Rabbit
- 应用范围：
WB, FC
- 浓度：
1 mg/mL.
- 抗体名：
PALB2
- 规格：
50μl/100μl
| 规格： | 50μl | 产品价格： | ￥1125.0 |
|---|---|---|---|
| 规格： | 100μl | 产品价格： | ￥1875.0 |
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures.
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技术资料暂无技术资料 索取技术资料
PALB2
￥1125 - 1875
