KLH conjugated synthetic peptide derived from human FZR1/CDC20C 141-240/496
亚型:
IgG
形态:
Liquid
克隆性:
Rabbit polyclonal Antibody
标记物:
Non-conjugated
适应物种:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep
库存:
现货
供应商:
华安生物
宿主:
Rabbit
应用范围:
WB, IHC-P
浓度:
1 mg/mL.
抗体名:
FZR1
规格:
50μl/100μl
规格:
50μl
产品价格:
¥1125.0
规格:
100μl
产品价格:
¥1875.0
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.