KLH conjugated synthetic peptide derived from human ERCC8/CSA 161-260/396
亚型:
IgG
形态:
Liquid
克隆性:
Rabbit polyclonal Antibody
标记物:
Non-conjugated
适应物种:
Human, Mouse, Rat, Horse
库存:
现货
供应商:
华安生物
宿主:
Rabbit
应用范围:
WB, IHC-P
浓度:
1 mg/mL.
抗体名:
ERCC8
规格:
50μl/100μl
规格:
50μl
产品价格:
¥1125.0
规格:
100μl
产品价格:
¥1875.0
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.