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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Synthesized peptide derived from human protein . at AA range: 40-120
- 亚型:
IgG
- 形态:
Liquid
- 克隆性:
Rabbit polyclonal Antibody
- 标记物:
Non-conjugated
- 适应物种:
Human, Rat, Mouse
- 库存:
现货
- 供应商:
华安生物
- 宿主:
Rabbit
- 应用范围:
WB
- 浓度:
1 mg/mL.
- 抗体名:
ACSL3
- 规格:
50μl/100μl
| 规格: | 50μl | 产品价格: | ¥1125.0 |
|---|---|---|---|
| 规格: | 100μl | 产品价格: | ¥1875.0 |
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.
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文献和实验相关实验
「又现叛徒」,Nature发现淋巴竟然会为癌细胞「打掩护」,帮助其「逃亡」
差异,发现淋巴结中的癌细胞含有较高含量的单不饱和脂肪酸 —— 油酸(橄榄油的主要成分)。用油酸预处理黑色素瘤细胞,可提高其血液转移的过程中的存活能力,而多不饱和脂肪酸亚油酸则不能。进一步的实验发现,ACSL3 可帮助油酸掺入淋巴中癌细胞的膜中,稀释细胞膜上的多不饱和脂肪酸,从而抑制了铁死亡的发生。最后,作者从同一个供体小鼠的皮下原发肿瘤和淋巴结转移瘤中分离出小鼠黑素瘤细胞,并将其通过静脉移植到另一只小鼠中。与来自皮下的黑色素瘤细胞相比,来自淋巴结的肿瘤细胞更容易形成转移性肿瘤。研究总结本研究表明
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ACSL3
¥1125 - 1875






