- ￥1125 - 1875
- HuaBio/华安生物
- 华安生物
- ER1911-31
- 2025年10月10日
- WB, IHC-P, FC
- Rabbit
- Human, Mouse, Rat, Dog
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- 详细信息
- 技术资料
- 免疫原：
KLH conjugated synthetic peptide derived from human IL-22 35-179/179
- 亚型：
IgG
- 形态：
Liquid
- 克隆性：
Rabbit polyclonal Antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat, Dog
- 库存：
现货
- 供应商：
华安生物
- 宿主：
Rabbit
- 应用范围：
WB, IHC-P, FC
- 浓度：
1 mg/mL.
- 抗体名：
IL22
- 规格：
50μl/100μl
| 规格： | 50μl | 产品价格： | ￥1125.0 |
|---|---|---|---|
| 规格： | 100μl | 产品价格： | ￥1875.0 |
-
概述
- 产品描述Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 is produced by several populations of immune cells at a site of inflammation. Producers are αβ T cells classes Th1, Th22 and Th17 along with γδ T cells, NKT, ILC3, neutrophils and macrophages. IL-22 takes effect on non-hematopoietic cells – mainly stromal and epithelial cells. Effects involve stimulation of cell survival, proliferation and synthesis of antimicrobials including S100, Reg3β, Reg3γ and defensins. IL-22 thus participates in both wound healing and in protection against microbes. IL-22 dysregulation takes part in pathogenesis of several autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and psoriasis. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.
- 产品名称Anti-IL22 antibody
- 分子量17 KDa
- 种属反应性Human,Mouse,Rat,Dog
- 验证应用WB,IHC-P,FC
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human IL-22 35-179/179
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Protein A affinity purified.
- 亚细胞定位Secreted.
- 数据链接SwissProt: Q9GZX6 Human
- 其它名称
- Interleukin-22
- Il22
- IL-22
-
应用
WB:1:500-2000
IHC-P:1:400-800
FC:1μg /test
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IL22
￥1125 - 1875
