- ￥1125 - 1875
- HuaBio/华安生物
- 华安生物
- EM1707-09
- 2025年07月11日
- WB, IHC-P
- Mouse
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein
- 亚型：
IgG1
- 形态：
Liquid
- 克隆性：
Mouse monoclonal Antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 库存：
现货
- 供应商：
华安生物
- 宿主：
Mouse
- 应用范围：
WB, IHC-P
- 浓度：
2 mg/mL.
- 抗体名：
SIRT7
- 规格：
50μl/100μl
| 规格： | 50μl | 产品价格： | ￥1125.0 |
|---|---|---|---|
| 规格： | 100μl | 产品价格： | ￥1875.0 |
Sirtuins (SIRT1-7) are human homologs of the yeast Sir2 (silent information regulator-2) protein and are divided into four main classes: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. In S. cerevisiae, Sir2 deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA (ribosomal DNA) and silent mating-type loci. The human SIRT proteins are NAD-dependent deacetylases that act as intracellular regulators and are thought to have ribosyltransferase activity. SIRT7 (NAD-dependent deacetylase sirtuin-7), also known as SIR2L7, is a member of the class IV sirtuin family and is localized to the nucleolus. Expressed throughout the body, SIRT7 associates with rDNA genes where it interacts with histones and acts as a positive regulator of RNA polymerase I (Pol I). SIRT7 is a probable NAD-dependent deacetylase whose expression is upregulated in thyroid carcinoma cells. Overexpression of SIRT7 increases Pol I-mediated transcription, thereby speeding cell growth and contributing to the development of cancer. Two isoforms exist due to alternative splicing events.
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文献和实验相关实验
粒细胞的扩增，可引发小叶乳腺癌 GEM 模型的自发性转移形成，导致 GEM 移植模型的自发转移疾病。GEM 模型在揭示相关基因参与抑制肿瘤转移机制方面也发挥了重要作用。最近，刘宝华课题组应用 Tet-ON 可诱导 Sirt7 表达的 GEM 模型，揭示了 Sirt7 抑制原发胰腺癌转移作用机制，该研究结果证实，由 Dox 诱导表达的 Sirt7 具有明显抑制 MMTV-PyMT 小鼠乳腺肿瘤肺转移的作用，且其作用机制是通过调节 TGF-β信号通路实现的。因此，GEM 模型在揭示肿瘤转移复杂性，挑战当下普遍
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SIRT7
￥1125 - 1875
