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文献和实验alkyne?azide cycloaddition (CuAAC) reaction has been used to synthesize cyclic mini?DNA duplexes. The reaction is carried out on 5??alkyne?3??azide?labeled hairpin loop oligonucleotides and proceeds in high yield under mild conditions in as little as 5
Natural Product Chemistry in Action: The Synthesis of Melatonin Metabolites K1 and K2
) ortho -lithiation-iodination with tert -butyllithium-1,2-iodoethane, (c) use of the Sonogashira reaction with N -acetyl propargylamine, and (d) sequential alkyne hydration/formylation to give (K1 ) or alkyne to give (K2 ).
Synthesis of Azido-Functionalized Carbohydrates for the Design of Glycoconjugates
for the design of glycoconjugates based on a series of conjugation methodologies. The recent development of copper(I)-catalyzed azide-alkyne cycloaddition (CuACC) paved the way to a novel conjugation strategy in which azido-functionalized carbohydrate derivatives
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