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- YC#01342
- 2025年07月12日
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- 详细信息
- 技术资料
- 库存：
大量
- 保质期：
-20℃ for 2 years
- 供应商：
sun-shinechem, 上海永璨
- 英文名：
Apremilast,CC-10004
- 规格：
50ug
Apremilast
http://www.sun-shinechem.com/608141-41-9.html
CAS No.：608141-41-9
Formula：C22H24N2O7S
M.Wt：460.50
Purity：>98％
Storage：-20℃ for 2 years
Apremilast is a novel, orally available PDE4 inhibitor that inhibits spontaneous TNFα production from human rheumatoid synovial membrane cultures, ex-vivo, with similar efficacy to rolipram. In addition, apremilast effectively reduced the severity of both mAb-induced arthritis and CIA in BALB/c and DBA/1 mice, respectively, over 10 days post onset, without any evident side effects, often associated with classical PDE4 inhibitors such as rolipram. Taken together, our results show that apremilast has therapeutic potential for the treatment of RA and other chronic inflammatory conditions where TNFα plays a major pathological role
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