AZD4694,1054629-49-0

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AZD4694

CAS No. : 1054629-49-0

MCE 国际站：AZD4694

产品活性：AZD4694 (NAV4694) 是一种氟化 β-淀粉样蛋白 (Aβ) 斑块神经成像的 PET 放射配基，对 Aβ纤维具有高度亲和力 (K_d = 2.3 nM)。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vivo: Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue.
AZD4694 (4 mL/kg; intravenous injection) inhibits [³H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.

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